seizures. Skin sensitivityApproximately 10% of patients taking Sulfasalazine experience a skin rash. Do not crush, chew, or break the delayed-release tablets (Azulfidine EN-tabs®). The more common side effects that can occur with sulfasalazine include: ... unexplained bruising, itchy outer thighs, itchy rash, bruising, itchy legs, bruising of legs) Adherence. Stomach Cramps 11. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Fertility returns when the medicine is stopped. abdominal pain Strength(s): 500 MG Sulfasalazine is a prodrug that is metabolized to its active components, sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine); beneficial effects are predominantly from the anti-inflammatory properties of 5-ASA, which inhibits leukotriene synthesis and lipoxygenase. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines. Take sulfasalazine exactly as directed by your doctor. Sulfasalazine is an anti-inflammatory medication consisting of a combination of 5-aminosalicylic acid and the sulphonamide sulfapyridine. In addition, delayed-release tablets of sulfasalazine are used to treat rheumatoid arthritis and juvenile rheumatoid arthritis. Continue to take sulfasalazine and talk to your doctor if you experience: nausea, vomiting, or decreased appetite Side effects can occur earlier. When taking Sulfasalazine, reported side effects are usually mild and improve in time. Learn from their experiences about effectiveness, side effects and cost. CAS nº: 599-79-1 Sulfasalazine oral tablet may cause drowsiness. Manufacturer: PHARMACIA / UPJHN. Imprint: KPH | 102 If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Throwing Up Also tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back. What are the common or serious side effects of sulfasalazine? Appetite loss 6. Nausea/vomiting 4. Trouble breathing 14. Portions of this document last updated: Dec. 01, 2020. Serious skin reactions can occur with this medicine. Early treatment of rheumatoid arthritis with sulfasalazine helps to reduce and even prevent further joint damage so you can do more of your normal daily activities. headaches. Sulfasalazine Side Effects Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. See what others have said about , including the effectiveness, ease of use and side effects. After an attack is treated, sulfasalazine is also used to increase the amount of time between attacks. The exact way that sulfasalazine works is unknown, but it is believed to reduce the actions of substances in the body that cause inflammation, tissue damage, and diarrhea. Saw GP who suggested that this was the cause recommended I stopped taking the medication & gave me a course of antihistamine contacted my Rheumy who agreed with the course of action. Hi Fellow RA sufferers, after 7 months of taking Sulfasalazine I've had to stop due to a nasty rash & terrible itching on my arms lower legs & back. Please visit the official site of the FDA for further information. Below you will find images and specific information on the principal types of sulfasalazine that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors. Always keep this medication in the container it came in, tightly closed, and out of reach of children. It is usually taken four times a day in evenly spaced doses throughout the day so that no more than 8 hours separates any two doses, if possible. a rash, itching, or hives The safety and effectiveness of sulfasalazine have not been established for children younger than 2 years of age. Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible. fever Some patients may require a product with a higher SPF number, especially if they have a fair complexion. When you begin taking this medicine: If you have a severe reaction from the sun, check with your doctor. Skin Discoloration 10. Diarrhea 3. However, if the victim has collapsed or is not breathing,  then please call the local emergency services immediately on 911. nausea When you begin taking this medicine: The enteric-coated formulation of Azulfidine EN-tabs® was specifically designed to reduce the likelihood of nausea and stomach upset. Side effects — The major side effects of sulfasalazine can be classified according to how frequently the side effect occurs: commonly, uncommonly, and rarely. Itching 4. Common side effects may include: nausea, vomiting, upset stomach, loss of appetite; headache; rash; or low sperm count in men. This medicine may decrease the amount of sperm men make and affect their ability to have children. These may be signs that you have an infection. Sulfasalazine may also decrease folate (a natural vitamin) in your body. Copyright © 2020 IBM Watson Health. Your skin or urine may turn an orange or yellow color while you or your child are using this medicine. Manufacturer: PHARMACIA / UPJHN. Apply a sun block lipstick that has an SPF of at least 15 to protect your lips. More common side effects. Dizzy 4. Aching of muscles black, tarry stools blistering, peeling, or loosening of the skin bloating blood in the urine or stools bloody diarrhea bluish fingernails, lips, or skin chest pain constipation cough difficulty with swallowing dizziness fainting spells fast heartbeat … bruising Imprint: G 500 Sulfasalazine causes temporary infertility in males. Do not stop taking sulfasalazine, even if you begin to feel better, without first talking to your doctor. If you have any questions, talk to your pharmacist about the proper disposal of your medication. Tell your doctor if you have any kind of infection before you start using this medicine. This content does not have an Arabic version. The sections below will provide you with more specific information and guidelines related to sulfasalazine and its correct use. Your doctor may want to monitor the digoxin levels in your blood if you are taking this medicine. This site complies with the HONcode standard for trustworthy health information: verify here. Moreover, sulfasalazine passes into breast milk and the effects of sulfasalazine on a nursing infant are not known. Distributor: MAJOR PHARMACEUTICALS. A … You may be able to increase the dose again after a while if your reaction to sulfasalazine improves and it’s helping your symptoms. Swallow them whole. Strength(s): 500 MG Loss Of Appetite 8. It is very important that your doctor check your or your child's progress at regular visits. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Common side effects — The most common side effects of sulfasalazine are headache, nausea, fever, rash, and reversible infertility in men. These may be symptoms of a blood problem. SULFASALAZINE IS a common therapeutic drug used to treat inflammatory bowel disease, rheumatoid arthritis, and psoriatic arthritis. This medication works by reducing irritation and swelling in the large intestines. (sul fa sal’ a zeen). Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Call your doctor right away if you start to have a cough that won't go away, weight loss, night sweats, fever, chills, or flu-like symptoms, such as a runny or stuffy nose, headache, blurred vision, or feeling generally ill. Please do not take a double dose of this medication. The present article is a detailed review of the pharmacology, modes of action, side effects, and contraindications of sulfasalazine, along with an up-to-date review of the evidence underlying its use in various dermatological conditions. Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. Lack of desire 18. nausea 19. nosebleed… Sulfasalazine may decrease the absorption of digoxin (Lanoxin®, Lanoxicaps®). Do not use a sunlamp or tanning bed or booth. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment. Imprint: 104 Azulfidine EN-tabs® is the only formulation of sulfasalazine approved by the FDA for the treatment of both juvenile and adult RA. Diarrhea 3. All rights reserved. If you experience any of the following serious side effects, stop taking sulfasalazine and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives) worsening colitis (fever, abdominal pain, cramping, or bloody diarrhea) Do not take sulfasalazine without first talking to your doctor if you are breast-feeding a baby. Check with your doctor right away if you or your child have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. Never taken as prescribed Burden. These could be symptoms of a serious liver problem. What side effects can this medication cause? Sulfasalazine is sold under the brand name Azulfidine® in the United States. The study is created by eHealthMe based on reports (from sources including the FDA) of 611,156 people who take Sulfasalazine and Enbrel, and is updated regularly. Strength(s): 500 MG Check with your doctor right away if you or your child have blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine. Imprint: V | 5905 Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Imprint: KPH | 101 Mayo Clinic does not endorse companies or products. If you are interested to acquire this site, please contact us. Sulfasalazine has also been used for some skin conditions. If any of these effects persist or worsen, notify your doctor or … orange-yellow discoloration of the skin or urine (not harmful). Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter. Blood and urine tests will be needed to check for unwanted effects. If you experience any of the following serious side effects, stop taking sulfasalazine and seek emergency medical attention or notify your doctor immediately: an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue, or face, or hives) It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. It is very important to continue taking sulfasalazine to control your condition. Temperature 15. general body swelling 16. decreased sperm production (uncommon and usually reversible) Sulfasalazine (SSZ), sold under the trade name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn’s disease. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Upset stomach 2. Please remember to throw away any medication that is outdated or no longer needed. Inflammation Of Skin Caused By An Allergy 3. The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor. Back, leg, or stomach pains 9. bleeding gums 10. bluish colour of the fingernails, lips, skin, palms, or nail beds 11. chills 12. In the case of an overdose, call your local poison control center on 1-800-222-1222. You may need to take folate supplements or eat folate-rich foods. More research is needed to uncover the full potential of sulfasalazine in dermatology. Abnormal Urine Color 2. Manufacturer: URL/MUTUAL PHARMACEUTICALS, Name: SULFASALAZINE If experienced, these tend to have a Severe expression 1. Rash was 4+ acute and covered 100% of the body. Sulfasalazine was approved by the Food and Drug Administration in 1950. A prescription is required for this medicine. What are the possible side effects of sulfasalazine? Manufacturer: GREENSTONE LTD. Name: AZULFIDINE® Do not take sulfasalazine without first talking to your doctor if you have ever had an allergic reaction to sulfasalazine, a sulfa-based antibiotic, or aspirin; an obstruction (blockage) in your intestines or urinary tract; porphyria; liver disease; kidney disease; asthma; or glucose-6-phosphate dehydrogenase deficiency. The most common side effect of sulfasalazine is headache, and this is the main reason why some patients cannot take the drug. - Rash had the appearance of an exfoliative dermatitis bordering on a SJ syndrome (diffuse MP rash with an erythematous/scaly background); there were no oral lesions. Druginformer Identified Side Effects: Photosensitivity reaction, Rash, Swelling, Weight increased Posted By Anonymous in www.everydayhealth.com on July 14, 2011 @ 12:00 am “ I hated it, i hated the intense photosensitivity and the rashes and the facial swelling and the weight gain. Most patients start to feel the positive effects of at 4-8 weeks, with maximum benefit at 3-6 months. rashes. received an overall rating of 6 out of 10 stars from 10 reviews. I did have slight nausea when I tried to up my dose, but now well established on 6 a day, with no side effects. Pee that is dark 13. Commonly these include loss of appetite, nausea, headache, and rash. If you have any questions about this, check with your health care professional.